Renal Inhibition of Pressor Responses to Drugs | Zendy

J. W. McCubbin | Zendy; Irvine H. Page | Zendy

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Renal Inhibition of Pressor Responses to Drugs

Author(s) -

J. W. McCubbin,

Irvine H. Page

Publication year - 1954

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.2.1.35

Subject(s) - pressor response , excretory system , kidney , endocrinology , medicine , renal function , nephrectomy , inhibitory postsynaptic potential , central nervous system , pharmacology , chemistry , blood pressure , heart rate

Bilateral nephrectomy selectively augments reactivity to pressor drugs and affects that to angiotonin the most prominently. This change is not mediated through the central nervous system, does not depend upon mechanical exclusion of the renal vascular bed, and is not modified by change in sodium intake. The inhibitory action on pressor responsiveness is independent of renal excretory function.

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