Open AccessEffect of Chlorothiazide on Response of Renal Vascular Bed to Vasoactive Substances
Author(s) -
Jay Y. Gillenwater,
Jerry B. Scott,
Edward D. Fröhlich
Publication year - 1962
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.11.2.283
Subject(s) - chlorothiazide , vasoactive , epinephrine , constriction , renal artery , medicine , pressor response , angiotensin ii , vasoconstrictor agents , norepinephrine , vascular resistance , endocrinology , kidney , blood pressure , diuretic , heart rate , dopamine
In the anesthetized dog, administration of an isosmotic solution of chlorothiazide into the renal artery failed to affect renal vascular resistance but did acutely attenuate the constriction produced by intra-arterial injection of l-epinephrine, levarterenol, and Val-5-angiotensin II and potentiated the dilation produced by intra-arterial injection of MgCl2.
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