Distribution of 4-Iodoantipyrine After Intravenous Injection in the Rat | Zendy

John H. Flora | Zendy; Don F. Phillips | Zendy; Francesco Arcidiacono | Zendy; Leo A. Sapirstein | Zendy

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Distribution of 4-Iodoantipyrine After Intravenous Injection in the Rat

Author(s) -

John H. Flora,

Don F. Phillips,

Francesco Arcidiacono,

Leo A. Sapirstein

Publication year - 1962

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.11.2.252

Subject(s) - distribution (mathematics) , volume of distribution , chemistry , medicine , pharmacokinetics , mathematics , mathematical analysis

The distribution of 4-iodoantipyrine does not parallel that of body water, as evidenced by its overaccumulation in some organs and underaccumulation in others. These disparities occur largely because I131 is lost from the iodoantipyrine molecule, is converted to iodide, and is distributed and excreted as such. Any similarity between the distribution volume of iodoantipyrine and total body water is, therefore, happenstance.

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