The Metachromatic Activity of Urine Following the Injection of Heparin | Zendy

L. B. Jaques | Zendy; E. Napke | Zendy; S. W. Levy | Zendy

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The Metachromatic Activity of Urine Following the Injection of Heparin

Author(s) -

L. B. Jaques,

E. Napke,

S. W. Levy

Publication year - 1953

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/01.res.1.4.321

Subject(s) - metachromasia , urine , heparin , benzidine , chemistry , excretion , endocrinology , medicine , biochemistry , staining , pathology

Heparin was injected in man, dog, rabbit and sheep and the metachromatic activity (MA) of the urine measured directly or after precipitation with benzidine. The presence and amount of MA in the urine depended on route, size and time relations of the injection, but generally was much less than the MA of the heparin injected. An excretion product, uroheparin, has been described. It is concluded that following injection heparin may be (a) destroyed by heparinase, (b) degraded to uroheparin or (c) excreted unchanged. Following (b) or (c) metachromatic activity is found in the urine.

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