Biological actions of leukotrienes. State of the art lecture. | Zendy

A. W. FordHutchinson | Zendy; Gordon Letts | Zendy

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Biological actions of leukotrienes. State of the art lecture.

Author(s) -

A. W. FordHutchinson,

Gordon Letts

Publication year - 1986

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.8.6_pt_2.ii44

Subject(s) - leukotriene , arachidonic acid , vasodilation , vasoconstriction , leukotriene c4 , lipid signaling , vascular permeability , psoriasis , lipoxygenase , arachidonate 5 lipoxygenase , in vivo , bradykinin , pharmacology , chemistry , inflammation , medicine , endocrinology , immunology , biology , enzyme , asthma , biochemistry , receptor , microbiology and biotechnology

Leukotrienes are novel mediators derived from arachidonic acid through the 5-lipoxygenase enzyme system. Leukotriene B4 has potent effects on leukocyte function and in vivo induces leukocyte accumulation and changes in vascular permeability and modulates pain responses. Peptido-lipid leukotrienes are potent smooth muscle--contracting agents. They may have important cardiovascular actions through mechanisms involving either vasoconstriction or indirect vasodilatation. Evidence for leukotriene production has been found in subjects with allergic conditions and psoriasis, indicating a putative role for these substances in human disease.

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