Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism. | Zendy

A. Ganguly | Zendy; M H Weinberger | Zendy; Gordon P. Guthrie | Zendy; Naomi S. Fineberg | Zendy

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Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism.

Author(s) -

A. Ganguly,

M H Weinberger,

Gordon P. Guthrie,

Naomi S. Fineberg

Publication year - 1984

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.6.4.563

Subject(s) - primary aldosteronism , medicine , endocrinology , aldosterone , corticosterone , glucocorticoid , hyperaldosteronism , mineralocorticoid , adrenocorticotropic hormone , adrenal cortex , renin–angiotensin system , blood pressure , hormone

To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18-hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality.

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