Connective tissue accumulation in the left coronary artery of young SHR. | Zendy

Piero Anversa | Zendy; M Melissari | Zendy; A Tardini | Zendy; G Olivetti | Zendy

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Connective tissue accumulation in the left coronary artery of young SHR.

Author(s) -

Piero Anversa,

M Melissari,

A Tardini,

G Olivetti

Publication year - 1984

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.6.4.526

Subject(s) - ground substance , elastin , medicine , connective tissue , artery , endoplasmic reticulum , smooth muscle , cardiology , left coronary artery , endocrinology , anatomy , pathology , chemistry , biochemistry

The left coronary artery of 21-, 28-, and 45-day-old spontaneously hypertensive rats and Wistar-Kyoto rats was analyzed morphometrically to evaluate the structural alterations of the vessel wall during the development of genetically determined hypertension. In 45-day-old rats, hypertension was associated with a significant expansion of the partial volume of collagen and ground substance (119%) within the arterial wall. This change exceeded the concurrent accumulation of elastin (77%) and smooth muscle cell mass (34%). The growth of the muscle compartment was also characterized by a marked increment of rough endoplasmic reticulum (103%). The increase in the mural concentration of fibrous proteins at this early age may be viewed as the initial adverse effect of hypertension on muscular arteries.

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