Membrane mechanisms in arterial hypertension. | Zendy

David R. Harder | Zendy; Kent Hermsmeyer | Zendy

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Membrane mechanisms in arterial hypertension.

Author(s) -

David R. Harder,

Kent Hermsmeyer

Publication year - 1983

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.5.4.404

Subject(s) - medicine , vascular smooth muscle , contraction (grammar) , endocrinology , spontaneously hypertensive rat , pathophysiology of hypertension , essential hypertension , renin–angiotensin system , cardiology , chemistry , blood pressure , smooth muscle

The purpose of this review is to focus on alterations in vascular muscle membrane potentials (Em), ionic permeabilities, and ionic transport systems which may either contribute to or be a consequence of the hypertensive state. Three models of hypertension are discussed: 1) deoxycorticosterone-salt (DOCA-salt)-induced hypertension; 2) low-renin (presumably volume expanded) renal hypertension (LRRH); and 3) the spontaneously hypertensive rat (SHR) of the Okamoto-Aoki Kyoto-Wistar strain and its normotensive genetic control (WKY). The importance of studying all possible mechanisms of increased contraction in vascular smooth muscle is stressed.

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