Vascular Stiffness in Women With Systemic Lupus Erythematosus
Author(s) -
Faith Selzer,
Kim Sutton-Tyrrell,
Shirley G. Fitzgerald,
Russell P. Tracy,
Lewis H. Kuller,
Susan Manzi
Publication year - 2001
Publication title -
hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.986
H-Index - 265
eISSN - 1524-4563
pISSN - 0194-911X
DOI - 10.1161/01.hyp.37.4.1075
Subject(s) - medicine , pulse wave velocity , arterial stiffness , blood pressure , cardiology , population , risk factor , hydroxychloroquine , disease , environmental health , covid-19 , infectious disease (medical specialty)
Large-vessel manifestations of systemic lupus erythematosus (SLE), a multisystem disease characterized by disturbances in the immune system, include higher than expected rates of hypertension and cardiovascular disease. Reductions in the elasticity of central arteries may act as a marker of early changes that predispose to the development of major vascular disease. This study evaluated risk factors associated with aortic stiffness measured by pulse wave velocity (PWV) in women with SLE. We expected SLE-specific factors, especially variables indicative of inflammation and active disease, to be associated with increasing PWV. The study population included 220 women currently enrolled in the Pittsburgh Lupus
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