Angiotensin II and the Heart | Zendy

Walmor C. De Mello | Zendy; A.H. Jan Danser | Zendy

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Angiotensin II and the Heart

Author(s) -

Walmor C. De Mello,

A.H. Jan Danser

Publication year - 2000

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.35.6.1183

Subject(s) - intracrine , angiotensin ii , renin–angiotensin system , angiotensin ii receptor type 1 , medicine , contractility , endocrinology , receptor , paracrine signalling , blood pressure

-The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca(2+) current.

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