Genome Scan for Blood Pressure Loci in Mice | Zendy

Fred A. Wright | Zendy; Daniel T. O’Connor | Zendy; Elizabeth A. Roberts | Zendy; Greg Kutey | Zendy; Charles C. Berry | Zendy; Lisa U. Yoneda | Zendy; David S. Timberlake | Zendy; Gunther Schlager | Zendy

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Genome Scan for Blood Pressure Loci in Mice

Author(s) -

Fred A. Wright,

Daniel T. O’Connor,

Elizabeth A. Roberts,

Greg Kutey,

Charles C. Berry,

Lisa U. Yoneda,

David S. Timberlake,

Gunther Schlager

Publication year - 1999

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.34.4.625

Subject(s) - blood pressure , genome , genetics , medicine , biology , gene

Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was observed in the F2s on chromosome 10 (logarithm of the odds score [LOD]=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional suggestive LODs on chromosomes 2, 6, 8, and 18. In addition, several suggestive linkages were observed for phenotypes associated with human hypertension. Our study is the first reported genome-wide linkage scan for blood pressure genes in the mouse.

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