Endothelial Function in Hypertension | Zendy

Martin McIntyre | Zendy; David F. Bohr | Zendy; Anna F. Dominiczak | Zendy

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Endothelial Function in Hypertension

Author(s) -

Martin McIntyre,

David F. Bohr,

Anna F. Dominiczak

Publication year - 1999

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.34.4.539

Subject(s) - superoxide , nitric oxide , context (archaeology) , superoxide dismutase , enzyme , medicine , function (biology) , chemistry , endothelium , pharmacology , endocrinology , biochemistry , microbiology and biotechnology , biology , paleontology

Much attention has been focused on the role of nitric oxide in hypertension and cardiovascular disease. More recently, the role of superoxide anion and its interaction with nitric oxide has been investigated in this context. This review will concentrate on the role of superoxide in human and experimental hypertension, paying particular attention to the potential sources of superoxide within the vasculature and discussing some of the molecular mechanisms surrounding its production and dismutation. We discuss what is known about the human superoxide dismutase enzymes. We conclude that the balance between nitric oxide and superoxide is more important than the absolute levels of either alone.

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