Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17 | Zendy

Jader Baima | Zendy; Michael Nicolaou | Zendy; Faina Schwartz | Zendy; Anita L. DeStefano | Zendy; Athanasios Manolis | Zendy; Haralambos Gavras | Zendy; Cheryl L. Laffer | Zendy; Fernando Elijovich | Zendy; Lindsay A. Farrer | Zendy; Clinton T. Baldwin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17

Author(s) -

Jader Baima,

Michael Nicolaou,

Faina Schwartz,

Anita L. DeStefano,

Athanasios Manolis,

Haralambos Gavras,

Cheryl L. Laffer,

Fernando Elijovich,

Lindsay A. Farrer,

Clinton T. Baldwin

Publication year - 1999

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.34.1.4

Subject(s) - quantitative trait locus , genetics , genetic linkage , biology , locus (genetics) , chromosome , linkage (software) , synteny , gene , chromosome 4 , trait , chromosome 15 , computer science , programming language

Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage (P=0.0005) and refines the location of the blood pressure QTL.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research