Effects of fludrocortisone on sympathetic nerve activity in humans. | Zendy

Décio Mion | Zendy; Robert F. Rea | Zendy; Erling A. Anderson | Zendy; Daniel Kahn | Zendy; Christine A. Sinkey | Zendy; Allyn L. Mark | Zendy

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Effects of fludrocortisone on sympathetic nerve activity in humans.

Author(s) -

Décio Mion,

Robert F. Rea,

Erling A. Anderson,

Daniel Kahn,

Christine A. Sinkey,

Allyn L. Mark

Publication year - 1994

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.23.1.123

Subject(s) - fludrocortisone , placebo , endocrinology , medicine , norepinephrine , blood pressure , forearm , sympathetic nervous system , anesthesia , hydrocortisone , surgery , dopamine , alternative medicine , pathology

Fludrocortisone reduces plasma norepinephrine in healthy humans, but forearm vascular and pressor responses to norepinephrine are potentiated. The effects of fludrocortisone on sympathetic nerve activity in healthy humans are not known. To investigate these effects we evaluated muscle sympathetic nerve activity, heart rate, and arterial pressure in 11 healthy volunteers during three protocols: (1) before and on day 7 of fludrocortisone (0.4 mg/d) treatment with ad libitum diet (n = 6); (2) before and on day 7 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 7); and (3) before and on day 2 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 4). Placebo did not alter any parameter.(ABSTRACT TRUNCATED AT 250 WORDS)

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