Estrogen receptor variant and hypertension in women. | Zendy

Steven Lehrer | Zendy; Jill Rabin | Zendy; Tamara Kalir | Zendy; Beth S. Schachter | Zendy

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Estrogen receptor variant and hypertension in women.

Author(s) -

Steven Lehrer,

Jill Rabin,

Tamara Kalir,

Beth S. Schachter

Publication year - 1993

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.21.4.439

Subject(s) - allele , estrogen receptor , estrogen , medicine , incidence (geometry) , endocrinology , population , gynecology , physiology , genetics , biology , breast cancer , gene , cancer , physics , environmental health , optics

Eighty-eight women visiting a gynecologist were tested for an estrogen receptor B-variant allele. The women were ethnically and racially homogeneous to a large degree. They were from a suburb of Long Island, and most were white. The 12% incidence of hypertension in women with the estrogen receptor wild-type allele is comparable to the 13-32% incidence in the general population of women aged 55-64 years. However, the 48% incidence of hypertension in women with the estrogen receptor B-variant allele is considerably higher than in the general population of women in this age group. We conclude that the presence of the estrogen receptor B-variant allele might have increased the prevalence of hypertension in the women in this study.

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