Pharmacology of smooth muscle cell replication. | Zendy

Christopher L. Jackson | Zendy; Stephen M. Schwartz | Zendy

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Pharmacology of smooth muscle cell replication.

Author(s) -

Christopher L. Jackson,

Stephen M. Schwartz

Publication year - 1992

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.20.6.713

Subject(s) - restenosis , smooth muscle , cell growth , in vivo , vascular smooth muscle , receptor , cell , microbiology and biotechnology , pharmacology , myocyte , in vitro , biology , medicine , endocrinology , biochemistry , genetics , stent

The suggestion that smooth muscle cell proliferation contributes to hypertension, atherosclerosis, and restenosis after angioplasty has led to a growing interest in the use of drugs to inhibit this process. This review summarizes pharmacological studies of smooth muscle cell proliferation in vitro and in vivo and identifies specific mediators of proliferation that are implicated by drugs binding with high affinity to enzymes or receptors.

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