G protein-mediated ion channel activation. | Zendy

Gerda E. Breitwieser | Zendy

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G protein-mediated ion channel activation.

Author(s) -

Gerda E. Breitwieser

Publication year - 1991

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.17.5.684

Subject(s) - ion channel , trpc1 , guanine , chemistry , g protein , biophysics , potassium channel , second messenger system , receptor , nucleotide , ligand gated ion channel , microbiology and biotechnology , biochemistry , biology , gene

Guanine nucleotide binding proteins couple a wide variety of receptors to ion channels via both "direct" or membrane-delimited and "indirect" second messenger-mediated pathways. This tutorial summarizes current approaches to defining the mechanisms of guanine nucleotide binding protein-mediated ion channel activation. Two well-characterized ion channels in the heart, namely, the beta-adrenergic receptor-activated calcium channel and the muscarinic receptor-activated potassium channel, are used to illustrate the criteria that can distinguish between direct and indirect guanine nucleotide binding protein-transduced pathways.

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