Essential hypertension and histocompatibility antigens. A linkage study. | Zendy

Maria GerbaseDeLima | Zendy; J J DeLima | Zendy; Ligia B.L. Persoli | Zendy; Henrique B. da Silva | Zendy; M Marcondes | Zendy; Giovanni Bellotti | Zendy

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Essential hypertension and histocompatibility antigens. A linkage study.

Author(s) -

Maria GerbaseDeLima,

J J DeLima,

Ligia B.L. Persoli,

Henrique B. da Silva,

M Marcondes,

Giovanni Bellotti

Publication year - 1989

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.14.6.604

Subject(s) - essential hypertension , human leukocyte antigen , haplotype , etiology , genetic predisposition , histocompatibility , immunology , major histocompatibility complex , genetics , antigen , genetic linkage , biology , inheritance (genetic algorithm) , gene , medicine , allele , blood pressure

It is well established that genetic and environmental factors are involved in the etiology of essential hypertension. The presence of genes predisposing to essential hypertension in the human leukocyte antigen (HLA) complex is controversial because studies of an association between HLA antigens and essential hypertension have failed to yield consistent results. Our aim in the present study was to further investigate this issue through the method of linkage analysis. Analysis of 96 hypertensive siblings distributed in 31 families indicated a significant distortion (p = 0.0009) of the normal segregation pattern of inheritance of HLA haplotypes. Thus, our data indicate that at least one of the genes responsible for genetic predisposition to essential hypertension is located very near or within the HLA complex.

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