Drug interactions in hypertension. | Zendy

Andrew J. Wood | Zendy

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Drug interactions in hypertension.

Author(s) -

Andrew J. Wood

Publication year - 1988

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.11.3_pt_2.ii1

Subject(s) - pharmacology , drug , pharmacokinetics , antihypertensive drug , pharmacodynamics , medicine , homeostasis , drug metabolism , endocrinology , blood pressure

Interactions between drugs and antihypertensive agents can result in either increased or decreased antihypertensive effects. These interactions may be pharmacokinetic or pharmacodynamic in type, resulting in either altered plasma drug concentrations or altered drug effects at similar plasma concentrations. Drugs may limit the absorption of antihypertensive agents, alter their metabolism through either enzyme inhibition or induction, or change renal excretion. In addition, by altering cardiovascular and volume homeostasis, changes in antihypertensive response may be produced.

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