Blood Pressure in Mutant Rats Lacking the 5-Hydroxytryptamine Transporter | Zendy

Judith R. Homberg | Zendy; Josine Mudde | Zendy; Branko Braam | Zendy; Bart Ellenbroek | Zendy; Edwin Cuppen | Zendy; Jaap A. Joles | Zendy

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Blood Pressure in Mutant Rats Lacking the 5-Hydroxytryptamine Transporter

Author(s) -

Judith R. Homberg,

Josine Mudde,

Branko Braam,

Bart Ellenbroek,

Edwin Cuppen,

Jaap A. Joles

Publication year - 2006

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.0000246306.61289.d8

Subject(s) - blood pressure , transporter , mutant , medicine , endocrinology , biology , pharmacology , chemistry , genetics , gene

To the Editor:Although 5-HT uptake inhibitors are widely used as antidepressants, the role of 5-HT in the control of systemic blood pressure is far from clear.1 In a recent issue of Hypertension , Ni et al reported that 5-hydroxytryptamine (5-HT) transporter (SERT) expression was increased, whereas SERT function was decreased in aorta of rats with DOCA salt and Nω-nitro-L-arginine (L-NNA)-induced hypertension.2 We have observed that several 5-HT receptors are induced in leukocytes of hypertensive patients.3 These 2 observations could point at a functional response of the serotonin system …

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