Open AccessElastin Stabilizes an Infarct and Preserves Ventricular Function
Author(s) -
Tomohiro Mizuno,
Terrence M. Yau,
Richard D. Weisel,
Chris Kiani,
RenKe Li
Publication year - 2005
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.circulationaha.105.523795
Subject(s) - elastin , medicine , ventricular function , cardiology , function (biology) , myocardial infarction , microbiology and biotechnology , pathology , biology
After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a myocardial scar using cell based gene therapy.
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