Open AccessCardioprotective Effect of Angiotensin-Converting Enzyme Inhibition Against Hypoxia/Reoxygenation Injury in Cultured Rat Cardiac Myocytes
Author(s) -
Satoaki Matoba,
Tetsuya Tatsumi,
Natsuya Keira,
Akira Kawahara,
Kazuko Akashi,
Miyuki Kobara,
Jun Asayama,
Masao Nakagawa
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.6.817
Subject(s) - bradykinin , myocyte , angiotensin ii , endocrinology , medicine , hypoxia (environmental) , cyclooxygenase , nitric oxide synthase , angiotensin converting enzyme , ace inhibitor , pharmacology , receptor antagonist , antagonist , receptor , nitric oxide , chemistry , enzyme , biochemistry , organic chemistry , oxygen , blood pressure
Although ACE inhibitors can protect myocardium against ischemia/reperfusion injury, the mechanisms of this effect have not yet been characterized at the cellular level. The present study was designed to examine whether an ACE inhibitor, cilazaprilat, directly protects cardiac myocytes against hypoxia/reoxygenation (H/R) injury.
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