Chimeric DNA-RNA Hammerhead Ribozyme to Proliferating Cell Nuclear Antigen Reduces Stent-Induced Stenosis in a Porcine Coronary Model | Zendy

Aaron Frimerman | Zendy; Peter J. Welch | Zendy; Xiaomei Jin | Zendy; Neal Eigler | Zendy; Soonpin Yei | Zendy; James S. Forrester | Zendy; Hidehiko Honda | Zendy; Raj Makkar | Zendy; Jack R. Barber | Zendy; Frank Litvack | Zendy

Open Access

Chimeric DNA-RNA Hammerhead Ribozyme to Proliferating Cell Nuclear Antigen Reduces Stent-Induced Stenosis in a Porcine Coronary Model

Author(s) -

Aaron Frimerman,

Peter J. Welch,

Xiaomei Jin,

Neal Eigler,

Soonpin Yei,

James S. Forrester,

Hidehiko Honda,

Raj Makkar,

Jack R. Barber,

Frank Litvack

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.5.697

Subject(s) - hammerhead ribozyme , ribozyme , restenosis , proliferating cell nuclear antigen , microbiology and biotechnology , medicine , cell growth , stent , vascular smooth muscle , rna , biology , cancer research , gene , biochemistry , smooth muscle

Stent-induced coronary restenosis is a major clinical and public health problem. Proliferating cell nuclear antigen (PCNA) is an important regulator of cell division, and blocking of its expression after angioplasty may limit intimal proliferation.

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