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In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na+-Ca2+ exchanger.

Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium

Relationship Between Na ⁺ -Ca ²⁺ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium