Open AccessNPR-A–Deficient Mice Show Increased Susceptibility to Hypoxia-Induced Pulmonary Hypertension
Author(s) -
Lan Zhao,
Lü Long,
Nicholas W. Morrell,
Martin R. Wilkins
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.5.605
Subject(s) - medicine , hypoxic pulmonary vasoconstriction , hypoxia (environmental) , pulmonary artery , pulmonary hypertension , atrial natriuretic peptide , endocrinology , right ventricular hypertrophy , natriuretic peptide , ventricular pressure , cardiology , lung , blood pressure , heart failure , oxygen , chemistry , organic chemistry
Mice in which the gene encoding NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, has been disrupted were used to examine the contribution of natriuretic peptides to maintaining pulmonary vascular homeostasis in normal- and low-oxygen environments.
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