Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions | Zendy

Marianne Gwechenberger | Zendy; Leonardo H. Mendoza | Zendy; Keith A. Youker | Zendy; Nikolaos G. Frangogiannis | Zendy; C. Wayne Smith | Zendy; Lloyd H. Michael | Zendy; Mark L. Entman | Zendy

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Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions

Author(s) -

Marianne Gwechenberger,

Leonardo H. Mendoza,

Keith A. Youker,

Nikolaos G. Frangogiannis,

C. Wayne Smith,

Lloyd H. Michael,

Mark L. Entman

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.4.546

Subject(s) - myocyte , medicine , lymph , northern blot , tumor necrosis factor alpha , cardiac myocyte , cytokine , lipopolysaccharide , pathology , messenger rna , biology , gene , biochemistry

Previous work from our laboratory demonstrated that interleukin (IL)-6 plays a potentially critical role in postreperfusion myocardial injury and is the major cytokine responsible for induction of intracellular adhesion molecule (ICAM)-1 on cardiac myocytes during reperfusion. Myocyte ICAM-1 induction is necessary for neutrophil-associated myocyte injury. We have previously demonstrated the induction of IL-6 in the ischemic myocardium, and the current study addresses the cells of origin of IL-6.

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