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l -Arginine Normalizes Coronary Vasomotion in Long-Term Smokers
Author(s) -
Roxana Campisi,
Johannes Czernin,
Heiko Schöder,
James W. Sayre,
Heinrich R. Schelbert
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.4.491
Subject(s) - medicine , cold pressor test , vasomotion , arginine , blood pressure , endocrinology , coronary circulation , heart rate , blood flow , cardiology , chemistry , biochemistry , amino acid
Noninvasive measurements of myocardial blood flow (MBF) with PET revealed an abnormal coronary vasomotor response to cold pressor test in healthy long-term smokers. If coronary endothelial dysfunction accounted for this abnormality, we hypothesized that it could be reversed by L-arginine as the substrate for NO synthase.

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