Open AccessExpression of Tissue Inhibitor of Matrix Metalloproteinases 1 by Use of an Adenoviral Vector Inhibits Smooth Muscle Cell Migration and Reduces Neointimal Hyperplasia in the Rat Model of Vascular Balloon Injury
Author(s) -
C Dollery,
Steve E. Humphries,
Alan McClelland,
David S. Latchman,
Jean R. McEwan
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.24.3199
Subject(s) - timp1 , medicine , matrix metalloproteinase , neointimal hyperplasia , mmp9 , vascular smooth muscle , cell migration , in vivo , genetic enhancement , pathology , in vitro , endocrinology , gene expression , restenosis , downregulation and upregulation , biology , smooth muscle , stent , biochemistry , gene , microbiology and biotechnology
Cell migration is a major contributor to injury-induced neointimal hyperplasia and depends on alteration of the proteolytic balance within the arterial wall toward matrix breakdown. This is partly mediated by the matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs).
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