Open AccessMembrane Type 1 Matrix Metalloproteinase Expression in Human Atherosclerotic Plaques
Author(s) -
Tripathi B. Rajavashisth,
Xiaoping Xu,
Stefan Jovinge,
Simcha Meisel,
Xiao-Ou Helen Xu,
N. Chai,
Michael C. Fishbein,
Sanjay Kaul,
Bojan Cercek,
Behrooz G. Sharifi,
Prediman K. Shah
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.24.3103
Subject(s) - medicine , matrix metalloproteinase , metalloproteinase , matrix metalloproteinase 9 , pathology
Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques, where in their active form, they may contribute to vascular remodeling and plaque disruption. In this study, we tested the hypothesis that membrane type 1 MMP (MT1-MMP), a novel transmembrane MMP that activates pro-MMP-2 (gelatinase A), is expressed in human atherosclerotic plaques and that its expression is regulated by proinflammatory molecules.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom