Acetylsalicylic Acid Reduces Vegetation Bacterial Density, Hematogenous Bacterial Dissemination, and Frequency of Embolic Events in Experimental Staphylococcus aureus Endocarditis Through Antiplatelet and Antibacterial Effects | Zendy

Leon Iri Kupferwasser | Zendy; Michael R. Yeaman | Zendy; Shelley Shapiro | Zendy; Cynthia C. Nast | Zendy; Paul M. Sullam | Zendy; Scott G. Filler | Zendy; Arnold S. Bayer | Zendy

Open Access

Acetylsalicylic Acid Reduces Vegetation Bacterial Density, Hematogenous Bacterial Dissemination, and Frequency of Embolic Events in Experimental Staphylococcus aureus Endocarditis Through Antiplatelet and Antibacterial Effects

Author(s) -

Leon Iri Kupferwasser,

Michael R. Yeaman,

Shelley Shapiro,

Cynthia C. Nast,

Paul M. Sullam,

Scott G. Filler,

Arnold S. Bayer

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.21.2791

Subject(s) - staphylococcus aureus , medicine , fibrin , platelet , vegetation (pathology) , endocarditis , bacteria , diabetes mellitus , aspirin , microbiology and biotechnology , endocrinology , immunology , pathology , biology , genetics

Platelets are integral to cardiac vegetations that evolve in infectious endocarditis. It has been postulated that the antiplatelet aggregation effect of aspirin (ASA) might diminish vegetation evolution and embolic rates.

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