The Role of Endothelin-Converting Enzyme-1 in the Development of α 1 -Adrenergic-Stimulated Hypertrophy in Cultured Neonatal Rat Cardiac Myocytes | Zendy

Satoshi Kaburagi | Zendy; Koji Hasegawa | Zendy; Tatsuya Morimoto | Zendy; Makoto Araki | Zendy; Tatsuya Sawamura | Zendy; Τοmoh Masaki | Zendy; Shigetake Sasayama | Zendy

Open Access

The Role of Endothelin-Converting Enzyme-1 in the Development of α ₁ -Adrenergic-Stimulated Hypertrophy in Cultured Neonatal Rat Cardiac Myocytes

Author(s) -

Satoshi Kaburagi,

Koji Hasegawa,

Tatsuya Morimoto,

Makoto Araki,

Tatsuya Sawamura,

Τοmoh Masaki,

Shigetake Sasayama

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.2.292

Subject(s) - medicine , myocyte , myocardial hypertrophy , cardiac hypertrophy , endothelin 1 , muscle hypertrophy , adrenergic , endothelin receptor , endocrinology , cardiology , cardiac myocyte , enzyme , receptor , biochemistry , biology

Accumulating evidence suggests that the local synthesis of endothelin-1 (ET-1) plays a role in the development of heart failure in vivo. We investigated the role of endothelin-converting enzyme-1 (ECE-1), which mediates the conversion of big ET-1 to mature ET-1, in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.

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