Atherosclerosis in APOE*3-Leiden Transgenic Mice | Zendy

Esther Lutgens | Zendy; Mat J.A.P. Daemen | Zendy; Mark Kockx | Zendy; Pieter A. Doevendans | Zendy; Marten H. Hofker | Zendy; Louis M. Havekes | Zendy; Hein J.J. Wellens | Zendy; Ebo D. de Muinck | Zendy

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Atherosclerosis in APOE*3-Leiden Transgenic Mice

Author(s) -

Esther Lutgens,

Mat J.A.P. Daemen,

Mark Kockx,

Pieter A. Doevendans,

Marten H. Hofker,

Louis M. Havekes,

Hein J.J. Wellens,

Ebo D. de Muinck

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.2.276

Subject(s) - lesion , medicine , apoptosis , apolipoprotein e , macrophage , genetically modified mouse , pathology , cell , cholesterol , phenotype , transgene , in vitro , biology , disease , gene , genetics

This study documents (1) the progression of atherosclerosis along the entire arterial tree in APOE*3-Leiden mice after 1, 4, 6, 9, and 12 months of a high-fat/high-cholesterol (HFC) diet and (2) the amount and phenotype of DNA-synthesizing and apoptotic cells in different lesion types after 6 months of HFC diet.

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