Endothelin-1 and Blood Pressure After Inhibition of Nitric Oxide Synthesis in Human Septic Shock | Zendy

J.A. Avontuur | Zendy; Frans Boomsma | Zendy; Anton H. van den Meiracker | Zendy; Frank H. de Jong | Zendy; Hajo A. Bruining | Zendy

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Endothelin-1 and Blood Pressure After Inhibition of Nitric Oxide Synthesis in Human Septic Shock

Author(s) -

J.A. Avontuur,

Frans Boomsma,

Anton H. van den Meiracker,

Frank H. de Jong,

Hajo A. Bruining

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.2.271

Subject(s) - septic shock , nitrite , nitric oxide , medicine , blood pressure , sepsis , endothelin receptor , shock (circulatory) , vascular resistance , nitrate , endothelin 1 , endocrinology , anesthesia , chemistry , receptor , organic chemistry

The systemic hypotension during human sepsis has been ascribed to increased production of nitric oxide (NO). Therefore, inhibitors of NO synthesis have been used in the treatment of hypotension in patients with septic shock. In addition, NO production may inhibit the synthesis and vasoconstrictor effects of endothelin-1 (ET-1). In this study, we tested whether ET-1 contributed to the vasopressor action of the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in patients with severe septic shock.

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