Efficient and Stable Transduction of Cardiomyocytes After Intramyocardial Injection or Intracoronary Perfusion With Recombinant Adeno-Associated Virus Vectors | Zendy

E. C. Svensson | Zendy; Deborah J. Marshall | Zendy; Karen Woodard | Zendy; Hua Lin | Zendy; Fang Jiang | Zendy; Lein Chu | Zendy; Jeffrey M. Leiden | Zendy

Open Access

Efficient and Stable Transduction of Cardiomyocytes After Intramyocardial Injection or Intracoronary Perfusion With Recombinant Adeno-Associated Virus Vectors

Author(s) -

E. C. Svensson,

Deborah J. Marshall,

Karen Woodard,

Hua Lin,

Fang Jiang,

Lein Chu,

Jeffrey M. Leiden

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.2.201

Subject(s) - medicine , adeno associated virus , recombinant dna , transduction (biophysics) , cardiology , perfusion , virology , vector (molecular biology) , gene , genetics , biochemistry , biology , chemistry

The delivery of recombinant genes to cardiomyocytes holds promise for the treatment of a variety of cardiovascular diseases. Previous gene transfer approaches that used direct injection of plasmid DNA or replication-defective adenovirus vectors have been limited by low transduction frequencies and transient transgene expression due to immune responses, respectively. In this report, we have tested the feasibility of using intramyocardial injection or intracoronary infusions of recombinant adeno-associated virus (rAAV) vectors to program transgene expression in murine cardiomyocytes in vivo.

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