Open AccessEffectiveness of Clopidogrel and Aspirin Versus Ticlopidine and Aspirin in Preventing Stent Thrombosis After Coronary Stent Implantation
Author(s) -
Issam Moussa,
Mathew Oetgen,
Gary S. Roubin,
Antonio Colombo,
Xangdong Wang,
Sriram S. Iyer,
Roberta Maida,
Michael J. Collins,
Edward M. Kreps,
Jeffrey W. Moses
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.18.2364
Subject(s) - medicine , ticlopidine , clopidogrel , coronary stent , aspirin , thienopyridine , percutaneous coronary intervention , population , stent , loading dose , regimen , cardiology , surgery , anesthesia , myocardial infarction , restenosis , environmental health
Ticlopidine has been shown to reduce the incidence of stent thrombosis compared with warfarin, but it may cause serious hematological side effects. Clopidogrel, a new thienopyridine derivative, may be a safe alternative to ticlopidine. The aim of this study was to compare the safety and efficacy of clopidogrel and aspirin with those of ticlopidine and aspirin in patients undergoing coronary stent implantation.
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