Open AccessExpression of Endothelin-1, Endothelin-Converting Enzyme, and Endothelin Receptors in Chronic Heart Failure
Author(s) -
Oliver Zolk,
Jessika Quattek,
G. Sitzler,
Thomas O. Schrader,
Georg Nickenig,
Petra Schnabel,
Kohei Shimada,
Masaaki Takahashi,
Michael Böhm
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.99.16.2118
Subject(s) - endothelin receptor , medicine , endocrinology , autocrine signalling , heart failure , receptor , endothelin 1 , phosphoramidon , inotrope , endothelins , paracrine signalling
Elevated plasma levels of endothelin (ET)-1 have been reported in association with heart diseases, including heart failure. Furthermore, it has been suggested that ET-1 acts as a local autocrine/paracrine factor with biological activities such as vasoconstriction, mitogenesis, and inotropic effects on the heart. This study investigated alterations of ET-1, ET receptor, and endothelin-converting enzyme (ECE) expression in left ventricular myocardium from patients with end-stage heart failure.
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