Augmented Sympathetic Activation During Short-Term Hypoxia and High-Altitude Exposure in Subjects Susceptible to High-Altitude Pulmonary Edema | Zendy

Hervé Duplain | Zendy; L Vollenweider | Zendy; Alain Delabays | Zendy; Pascal Nicod | Zendy; Peter Bärtsch | Zendy; Urs Scherrer | Zendy

Open Access

Augmented Sympathetic Activation During Short-Term Hypoxia and High-Altitude Exposure in Subjects Susceptible to High-Altitude Pulmonary Edema

Author(s) -

Hervé Duplain,

L Vollenweider,

Alain Delabays,

Pascal Nicod,

Peter Bärtsch,

Urs Scherrer

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.13.1713

Subject(s) - medicine , hypoxia (environmental) , pulmonary edema , hypoxic pulmonary vasoconstriction , high altitude pulmonary edema , edema , pulmonary artery , pulmonary hypertension , anesthesia , sympathetic nervous system , hypoxemia , effects of high altitude on humans , cardiology , vasoconstriction , blood pressure , lung , anatomy , oxygen , chemistry , organic chemistry

Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. Cardiovascular adjustments to hypoxia are mediated, at least in part, by the sympathetic nervous system, and sympathetic activation promotes pulmonary vasoconstriction and alveolar fluid flooding in experimental animals.

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