Death of Smooth Muscle Cells and Expression of Mediators of Apoptosis by T Lymphocytes in Human Abdominal Aortic Aneurysms | Zendy

Eric Henderson | Zendy; YongJian Geng | Zendy; Galina K. Sukhova | Zendy; Anthony D. Whittemore | Zendy; James Knox | Zendy; Peter Libby | Zendy

Open Access

Death of Smooth Muscle Cells and Expression of Mediators of Apoptosis by T Lymphocytes in Human Abdominal Aortic Aneurysms

Author(s) -

Eric Henderson,

YongJian Geng,

Galina K. Sukhova,

Anthony D. Whittemore,

James Knox,

Peter Libby

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.1.96

Subject(s) - apoptosis , immunostaining , tunel assay , perforin , fas ligand , pathology , medicine , programmed cell death , cd8 , extracellular matrix , microbiology and biotechnology , biology , immunology , immunohistochemistry , immune system , biochemistry

Thinning of the tunica media and rarefaction of smooth muscle cells (SMCs) characterize aneurysmal aortas. Apoptosis determines the cellularity and morphogenesis of tissue. Macrophages and T lymphocytes infiltrate the wall of abdominal aortic aneurysms (AAAs) and produce death-promoting proteins (perforin, Fas, and FasL). This study investigated whether apoptosis occurs in association with the expression of these proteins.

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