Attenuation of Cyclic Nucleotide–Mediated Smooth Muscle Relaxation in Blacks as a Cause of Racial Differences in Vasodilator Function | Zendy

Carmine Cardillo | Zendy; Crescence M. Kilcoyne | Zendy; Richard O. Can | Zendy; Julio A. Panza | Zendy

Open Access

Attenuation of Cyclic Nucleotide–Mediated Smooth Muscle Relaxation in Blacks as a Cause of Racial Differences in Vasodilator Function

Author(s) -

Carmine Cardillo,

Crescence M. Kilcoyne,

Richard O. Can,

Julio A. Panza

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.1.90

Subject(s) - vasodilation , sodium nitroprusside , medicine , nitric oxide , endocrinology , forearm , endothelium , anatomy

Vasodilator reactivity is attenuated in normotensive blacks, and this may contribute to their enhanced susceptibility to hypertension and its complications. However, the mechanisms responsible for this phenomenon are unknown. We therefore studied nitric oxide (NO)-dependent and -independent vasorelaxation in healthy blacks and whites to investigate the nature of racial differences in vasodilator function.

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