Activation of β 2 -Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure | Zendy

Alberto J. Kaumann | Zendy; Sabine Bartel | Zendy; Peter Molenaar | Zendy; Louise Sanders | Zendy; Kylie M. Burrell | Zendy; Donathe Vetter | Zendy; Petra Hempel | Zendy; Peter Karczewski | Zendy; ErnstGeorg Krause | Zendy

Open Access

Activation of β ₂ -Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure

Author(s) -

Alberto J. Kaumann,

Sabine Bartel,

Peter Molenaar,

Louise Sanders,

Kylie M. Burrell,

Donathe Vetter,

Petra Hempel,

Peter Karczewski,

ErnstGeorg Krause

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.1.65

Subject(s) - phospholamban , epinephrine , medicine , endocrinology , phosphorylation , receptor , norepinephrine , cardiomyopathy , adrenergic receptor , troponin i , heart failure , biology , dopamine , biochemistry , myocardial infarction

Catecholamines hasten cardiac relaxation through beta-adrenergic receptors, presumably by phosphorylation of several proteins, but it is unknown which receptor subtypes are involved in human ventricle. We assessed the role of beta1- and beta2-adrenergic receptors in phosphorylating proteins implicated in ventricular relaxation.

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