Angiotensin II Type 2 Receptor Blockade Amplifies the Early Signals of Cardiac Growth Response to Angiotensin II in Hypertrophied Hearts | Zendy

Jozef Bartúnek | Zendy; Ellen O. Weinberg | Zendy; Minori Tajima | Zendy; Susanne Rohrbach | Zendy; Beverly H. Lorell | Zendy

Open Access

Angiotensin II Type 2 Receptor Blockade Amplifies the Early Signals of Cardiac Growth Response to Angiotensin II in Hypertrophied Hearts

Author(s) -

Jozef Bartúnek,

Ellen O. Weinberg,

Minori Tajima,

Susanne Rohrbach,

Beverly H. Lorell

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.99.1.22

Subject(s) - medicine , endocrinology , angiotensin ii , angiotensin ii receptor type 1 , receptor , stimulation , angiotensin receptor , phenylalanine , muscle hypertrophy , blockade , prazosin , renin–angiotensin system , biology , blood pressure , antagonist , amino acid , biochemistry

We have previously shown that the acute molecular growth response of new protein synthesis and protein kinase C activation in response to angiotensin II (Ang II) is altered in left ventricular (LV) hypertrophy compared with normal hearts. We have also shown an upregulation of Ang II type 2 (AT2) receptors in hypertrophied hearts relative to controls. Activation of AT2 receptors is proposed to counteract growth effects of AT1 receptor in response to Ang II. Thus, we tested the hypothesis that in hypertrophied hearts, the AT2 receptor mediates inhibitory effects on the new cardiac protein synthesis in response to acute Ang II stimulation.

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