Preformed IgG Antibodies Against Major Histocompatibility Complex Class II Antigens Are Major Risk Factors for High-grade Cellular Rejection in Recipients of Heart Transplantation | Zendy

Silviu Itescu | Zendy; Thomas Tung | Zendy; Elizabeth Burke | Zendy; Alan Weinberg | Zendy; Nader Moazami | Zendy; John H. Artrip | Zendy; Nicole SuciuFoca | Zendy; Eric A. Rose | Zendy; Mehmet C. Öz | Zendy; Robert E. Michler | Zendy

Open Access

Preformed IgG Antibodies Against Major Histocompatibility Complex Class II Antigens Are Major Risk Factors for High-grade Cellular Rejection in Recipients of Heart Transplantation

Author(s) -

Silviu Itescu,

Thomas Tung,

Elizabeth Burke,

Alan Weinberg,

Nader Moazami,

John H. Artrip,

Nicole SuciuFoca,

Eric A. Rose,

Mehmet C. Öz,

Robert E. Michler

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.8.786

Subject(s) - medicine , immunology , heart transplantation , antibody , histocompatibility , antigen , transplantation , major histocompatibility complex , donor specific antibodies , human leukocyte antigen

Preformed anti-HLA antibodies reacting specifically with donor lymphocytes have been associated with acute vascular rejection and early cardiac allograft failure. However, the effect of preformed anti-HLA antibodies directed against allogeneic major histocompatibility complex (MHC) class I or II antigens of a donor panel on heart transplantation outcome has not been extensively studied.

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