Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion | Zendy

Nikolaos G. Frangogiannis | Zendy; Merry L. Lindsey | Zendy; Lloyd H. Michael | Zendy; Keith A. Youker | Zendy; Robert B. Bressler | Zendy; Leonardo H. Mendoza | Zendy; Robert N. Spengler | Zendy; C. Wayne Smith | Zendy; Mark L. Entman | Zendy

Open Access

Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion

Author(s) -

Nikolaos G. Frangogiannis,

Merry L. Lindsey,

Lloyd H. Michael,

Keith A. Youker,

Robert B. Bressler,

Leonardo H. Mendoza,

Robert N. Spengler,

C. Wayne Smith,

Mark L. Entman

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.7.699

Subject(s) - medicine , cytokine , ischemia , reperfusion injury , mast (botany) , tumor necrosis factor alpha , myocardial ischemia , cardiology , mast cell , immunology

Neutrophil-induced cardiomyocyte injury requires the expression of myocyte intercellular adhesion molecule (ICAM)-1 and ICAM-1-CD11b/CD18 adhesion. We have previously demonstrated interleukin (IL)-6 activity in postischemic cardiac lymph; IL-6 is the primary stimulus for myocyte ICAM- 1 induction. Furthermore, we found that induction of IL-6 mRNA occurred very early on reperfusion of the infarcted myocardium. We hypothesized that the release of a preformed upstream cytokine induced IL-6 in leukocytes infiltrating on reperfusion.

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