Induction by Lysophosphatidylcholine, a Major Phospholipid Component of Atherogenic Lipoproteins, of Human Coronary Artery Smooth Muscle Cell Migration | Zendy

Masakazu Kohno | Zendy; Koji Yokokawa | Zendy; Kenichi Yasunari | Zendy; Mieko Minami | Zendy; Hiroaki Kano | Zendy; Takao Hanehira | Zendy; Junichi Yoshikawa | Zendy

Open Access

Induction by Lysophosphatidylcholine, a Major Phospholipid Component of Atherogenic Lipoproteins, of Human Coronary Artery Smooth Muscle Cell Migration

Author(s) -

Masakazu Kohno,

Koji Yokokawa,

Kenichi Yasunari,

Mieko Minami,

Hiroaki Kano,

Takao Hanehira,

Junichi Yoshikawa

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.4.353

Subject(s) - lysophosphatidylcholine , medicine , platelet derived growth factor receptor , growth factor , platelet derived growth factor , endocrinology , phospholipid , phosphatidylcholine , biology , biochemistry , receptor , membrane

The objectives of the present study were (1) to determine whether lysophosphatidylcholine (lyso-PC), a prominent component of oxidatively modified LDL, induces migration of human coronary artery smooth muscle cells (SMCs) and, if so, to clarify the mechanism, and (2) to investigate the possible interactions of lyso-PC and platelet-derived growth factor (PDGF)-BB, endothelin- (ET-1), adrenomedullin (AM), or vitamin E on SMC migration by the Boyden's chamber method.

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