Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes | Zendy

Keita Kunisada | Zendy; Eiroh Tone | Zendy; Yasushi Fujio | Zendy; Hideo Matsui | Zendy; Keiko YamauchiTakihara | Zendy; Tadamitsu Kishimoto | Zendy

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Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

Author(s) -

Keita Kunisada,

Eiroh Tone,

Yasushi Fujio,

Hideo Matsui,

Keiko YamauchiTakihara,

Tadamitsu Kishimoto

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.4.346

Subject(s) - glycoprotein 130 , myocyte , leukemia inhibitory factor , transfection , cardiac myocyte , stat protein , stat3 , mapk/erk pathway , medicine , microbiology and biotechnology , signal transduction , biology , janus kinase , endocrinology , cell culture , interleukin 6 , cytokine , genetics

gp130, a signal transducer of the IL-6-related cytokines, is expressed ubiquitously, including in the heart. The activation of gp130 in cardiac myocytes was reported to induce myocardial hypertrophy. The downstream side of gp130 consists of two distinct pathways in cardiac myocytes, one a Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, the other a mitogen-activated protein kinase (MAPK) pathway. In the present study, we examined whether the JAK/STAT pathway, especially the STAT3-mediated pathway, plays a critical role in gp130-dependent myocardial hypertrophy by transfecting wild-type and mutated-type STAT3 cDNA to cardiac myocytes.

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