Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes
Author(s) -
James D. Marsh,
Michael H. Lehmann,
Rebecca H. Ritchie,
Judith K. Gwathmey,
Glenn E. Green,
RICK J. SCHIEBINGER
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.3.256
Subject(s) - endocrinology , medicine , myocyte , androgen receptor , androgen , cardiac myocyte , atrial natriuretic peptide , dihydrotestosterone , receptor , muscle hypertrophy , testosterone (patch) , biology , hormone , prostate cancer , cancer
The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response.
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