Prevention of Aneurysm Development and Rupture by Local Overexpression of Plasminogen Activator Inhibitor-1 | Zendy

Éric Allaire | Zendy; David Hasenstab | Zendy; Richard D. Kenagy | Zendy; Barry Starcher | Zendy; M M Clowes | Zendy; Alexander W. Clowes | Zendy

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Prevention of Aneurysm Development and Rupture by Local Overexpression of Plasminogen Activator Inhibitor-1

Author(s) -

Éric Allaire,

David Hasenstab,

Richard D. Kenagy,

Barry Starcher,

M M Clowes,

Alexander W. Clowes

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.3.249

Subject(s) - zymography , urokinase , elastin , plasminogen activator , medicine , plasmin , plasminogen activator inhibitor 1 , tissue plasminogen activator , blot , matrix metalloproteinase , microbiology and biotechnology , pathology , immunology , biology , biochemistry , enzyme , gene

Arterial aneurysms exhibit a loss of elastin and an increase in the plasminogen activators urokinase plasminogen activator (u-PA) and tissue plasminogen activator (t-PA). Because u-PA, t-PA, and plasmin have a limited proteolytic activity against elastin, the role of plasminogen activators in the aneurysmal disease is unclear. To investigate this question, we overexpressed plasminogen activator inhibitor-1 (PAI-1), an inhibitor of t-PA and u-PA, in a rat model of aortic aneurysm.

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