Flow Regulation of 72-kD Collagenase IV (MMP-2) After Experimental Arterial Injury | Zendy

Hisham S. Bassiouny | Zendy; Ruo H. Song | Zendy; Xue Hong | Zendy; Ashok K. Singh | Zendy; Hrachya Kocharyan | Zendy; Seymour Glagov | Zendy

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Flow Regulation of 72-kD Collagenase IV (MMP-2) After Experimental Arterial Injury

Author(s) -

Hisham S. Bassiouny,

Ruo H. Song,

Xue Hong,

Ashok K. Singh,

Hrachya Kocharyan,

Seymour Glagov

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.2.157

Subject(s) - medicine , collagenase , matrix metalloproteinase , cardiology , pathology , biochemistry , enzyme , chemistry

MMP-2 plays a key role in basement membrane degradation and in the migration of proliferating smooth muscle cells after vascular injury. Because low flow and shear stress have been related to the localization and progression of intimal hyperplasia, we hypothesized that flow conditions modulate in vivo MMP-2 transcription and activity in a model of injury-induced intimal thickening.

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