Heterogeneous Expression and Activity of Endothelial and Inducible Nitric Oxide Synthases in End-Stage Human Heart Failure | Zendy

Mitsumasa Fukuchi | Zendy; Sabah N. A. Hussain | Zendy; Adel Giaid | Zendy

Open Access

Heterogeneous Expression and Activity of Endothelial and Inducible Nitric Oxide Synthases in End-Stage Human Heart Failure

Author(s) -

Mitsumasa Fukuchi,

Sabah N. A. Hussain,

Adel Giaid

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.98.2.132

Subject(s) - enos , medicine , heart failure , nitric oxide synthase , myocyte , cardiomyopathy , cardiology , nitric oxide , myocarditis , endothelial nos , ischemic cardiomyopathy , inflammation , endocrinology , ejection fraction

Recent reports have suggested that excessive amounts of endogenous NO may contribute to the myocardial dysfunction and injury in heart failure. In the present report, we investigate the cellular expression and activity of endothelial (eNOS) and inducible (iNOS) NO synthase in failing human hearts with special reference to the underlying lesion and drug therapy.

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