Open AccessRequisite Role of Cardiac Myocytes in Coronary α 1 -Adrenergic Constriction
Author(s) -
Christiane Tiefenbacher,
David V. DeFily,
William M. Chilian
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.98.1.9
Subject(s) - phenylephrine , myocyte , constriction , medicine , endocrinology , antagonist , endothelin receptor , adrenergic , cardiac myocyte , agonist , adenosine , cardiology , receptor , blood pressure
Alpha-adrenergic activation in vivo causes constriction of coronary arterioles, but, paradoxically, in vitro these microvessels do not contract to this stimulus. We hypothesized that cardiac myocytes have a requisite role in alpha1-adrenergic coronary arteriolar constriction through the release of myocyte-derived contractile factor(s).
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